Doublebase^™ Once

Product overview

A once daily, highly moisturising and protective emollient gel for the management of dry skin conditions such as eczema, psoriasis and ichthyosis.

• Effective when applied once a day - provides 24 hours’ hydration from 1 application.^1,2
• Provides significantly greater and longer-lasting skin hydration than comparator ointments.^1,2
• An effective, easy to apply³ and cosmetically acceptable³ alternative to ointment emollients.
• In addition to using it as a leave on applied emollient, Doublebase Once can also be used as a soap substitute for washing.

T.A.P.S.
The humectants in Doublebase Once help to hold water in the skin. They also form the Triple Action Protective System (T.A.P.S). In addition to the humectant action which helps to provide at least 24 hours' hydration to protect the skin, it also inhibits microbial growth so that more commonly used preservatives are not required. This may be preferable for those who are particularly sensitive to conventional preservatives. 

EVIDENCE

Doublebase Once is an advanced gel formulation that has been shown to be significantly more hydrating than comparator ointments.^1,2 

Doublebase Once has been shown to achieve greater and longer-lasting skin hydration than comparator ointment EPD* from a single application over 24 hours.¹

In a randomised double-blind trial in patients with dry skin comparing Doublebase Once with comparator ointment EPD for 24 hours after a single application: Doublebase Once has been shown to be approximately 2 times more hydrating than EPD, and approximately 4 times more hydrating than no treatment.¹

In a blinded randomised comparative ex-vivo human skin study, a single application of Doublebase Once was shown to be significantly more hydrating than two comparator ointments over a 24 hour period.² 

A single application of Doublebase Once has been shown to be significantly more hydrating than 3 applications of a comparator emollient cream over 24 hours, in a randomised comparative ex-vivo human skin study.⁴

^{To see the new study data visit}

When the Doublebase Once formulation was applied to dry skin once a day for 5 days² (n=94):

97% agreed that the emollient was easy to apply
94% agreed that it had a pleasant consistency, and
90% agreed that it absorbed well into the skin, following the first application.

After 5 days of using the formulation once per day,
93% agreed that it made their skin feel smoother and softer; and
94% agreed that the formulation soothed their skin.

References
1. Comparison of the skin hydration of Doublebase Once emollient with Epaderm Ointment in a 24-hour, single application study, in subjects with dry skin. Extract report summarising skin hydration results for wiped off sites. Data on file. Dermal Laboratories Ltd, Hitchin, UK. 

EPD* = Epaderm^® Ointment a registered trademark of Mölnlycke Health Care.

2. Antonijević MD & Karajčić J. Ointments or a gel emollient? Randomised and blinded comparison of the hydration effect on ex-vivo human skin. Data presented at the 17th European Academy of Dermatology and Venereology (EADV) Symposium, May 2022, Ljubljana, Slovenia.

3. Evaluation of performance and acceptability of a novel, long acting (24h) emollient gel. Data on file. Dermal Laboratories Ltd, Hitchin, UK.

4. Antonijević MD & Karajčić J. Randomised, open, comparative study of the hydration effect on ex-vivo human skin of two emollient formulations with different recommended application regimes. Data presented at the 17th European Academy of Dermatology and Venereology (EADV) Symposium, May 2022, Ljubljana, Slovenia.

Doublebase ONCE

100g tube £2.69 (NHS price ex. VAT)

500g pump dispenser £6.99 (NHS price ex. VAT)

On Drug Tariff for NHS prescription. Medical Device.

‘Doublebase’ is a trademark.

If you require a previous version of the leaflet (instructions for use) please contact us at info@dermal.co.uk. 

Key Information

patient information leaflet